News Archive 16-21

Based on the proposal of the rectors of Czech universities, the Josef, Marie and Zdeněk Hlávka Foundation awards talented university students every year. This is a prestigious award, the award ceremony is associated with the celebration of the holiday of November 17th. For the Faculty of Medicine in Pilsen, MUDr. Jáchym Rosendorf, Ph.D., a recent graduate of doctoral studies in Surgery, was awarded this prize for exceptional study results. In his study work, he focused on the development and application of nanofibrous materials for healing support in the digestive tract surgery. This is a topic that he continues to address also after the graduation. Last year, the award was given to MUDr. Richard Pálek, Ph.D., also from our laboratory, but the award ceremony did not take place until this year due to a coronavirus pandemic. We congratulate both recent graduates and wish them many more successes.

Students for the following Ph.D. study topics are sought in the doctoral study programme:

DNA damage and its repair in mitochondrial DNA, implications in cancer cell*

Tutor: Pavel Vodička

Telomere homeostasis in interaction with DNA damage response in solid carcinogenesis*

Tutor: Pavel Vodička

Genomic/chromosomal instability in relation to microenvironment in colorectal cancer*

Tutor: Ludmila Vodičková

Tumor heterogeneity in colorectal carcinogenesis*

Tutor: Veronika Vymetálková

MicroRNA profiling in hepatocellular carcinoma

Tutor: Filip Ambrozkiewicz

Immunohistochemical and transcriptional proling of dierent subregions in hepatocellular carcinoma

Tutor: Andriy Trailin

Modelling of vessel tree in porcine liver based on multi-domain CT scans*

Tutor: Miroslav Jiřík

Study of prognostic biomarkers and therapeutic targets in patients with gastrointestinal cancers

Tutor: Viktor Hlaváč

Application deadline: November 30, 2021

More about us: www.liskalab.eu, www.biomedic-plzen.cz, www.lfp.cuni.cz

Contact:

Barbora Stachová, barbora.stachova@lfp.cuni.cz

Tel: +420 377 593 467

Department of Science and Research

Charles University, Faculty of Medicine in Pilsen

*This topic could also be studied in Czech language

Postdoctoral positions in translational cancer research (molecular biologist, immunologist, bioinformatician).

For a European Union-funded project on translational cancer research, headed by Professor Kari Hemminki, several postdoctoral positions with different areas of expertize are currently sought to work in Biomedical Center, Faculty of Medicine, Charles University in Pilsen, Czech Republic. The focus will be initially on colorectal cancer. The aims are to assess genetic and cellular changes taking place in the progression of colorectal cancer from precursor tumors (adenomas) to single or multiple colorectal cancers and lastly to metastases.

More information at the Chaperon project website.

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, is seeking students for the following Ph.D. study topics in the doctoral study programme of Experimental Surgery:

• Study of genes important for origin and progression of malignant tumors with usage of bioinformatic analyisis (Tutor: Assoc. prof. Pavel Soucek, Ph.D.)

• Importance of transcriptome in prognosis and treatment response in patients with solid tumors and in experimental models (Tutor: Radka Vaclavikova, Ph.D.)

• Epigenetic regulation in colorectal carcinogenesis (Tutor: Pavel Vodicka, Ph.D.)

• Mapping of genomic instability in colorectal carcinogenesis (Tutor: Pavel Vodicka, Ph.D.)

• Tumor heterogeneity in colorectal carcinogenesis (Tutor: Veronika Vymetalkova, Ph.D.)

• Immune markers in progression of colorectal cancer  (Tutor: Prof. Kari Hemminki, Ph.D.)

• Genetic changes and gene expression in polyps progressing into colorectal cancer (Tutor: Prof. Kari Hemminki, Ph.D.)

• Telomere dysfunction in progression to colorectal cancer (Tutor: Prof. Kari Hemminki, Ph.D.)

Application deadline: April 30, 2020

Online applications and information: https://is.cuni.cz/studium/eng/prijimacky/

Contact: Daniela Vyzrálová | daniela.vyzralova@lfp.cuni.cz | Tel: +420 377 593 466, +420 773 768 811 | Department of Science and Research | Charles University, Faculty of Medicine in Pilsen

Each year, the international biotechnology enterprise Roche distributes the Czech DIGI@MED Awards to authors of innovative digital and mobile solutions in medicine and healthcare process optimization. The goal of the award is to support young innovators in their bold endeavours in utilizing digital technologies for better clinical care, health and well-being. The contenders were evaluated by a panel of renowned healthcare and IT professionals, who considered not only the benefits that the solutions offer to clinicians and pharmacists, but mainly their positive effects for patients.

One of the 2019 awardees is Miroslav Jirik, PhD., our labmate from the Biomedical Center, Faculty of Medicine in Pilsen, Charles University and also from the NTIS Centre, Faculty of Applied Sciences, University of West Bohemia, who has utilized the results of a multidisciplinary team from these two institutions by creating the software application LISA (Liver Surgery Analyser). The LISA application serves as a platform for research of liver perfusion. 3D modelling of virtual liver resection, which is also included in LISA, then extends the possibilities of current clinical care for patients with liver cancer by allowing surgeries at the margin of operability to be performed. The software also facilitates the estimation of the regeneration potential of the remaining liver tissue after resection. This substantial achievement was made possible by combining the latest findings of both technical and biomedical research thanks to the collaboration between the universities.

Dr. Jirik focuses on machine learning and computer vision methods in the field of medical applications. He represents a key link between the Biomedical Center and the technically oriented researchers from the University of West Bohemia.

Another Czech DIGI@MED Award was presented to Marek Vosecký for his mobile application CF Hero, which helps young patients suffering from cystic fibrosis. An honourable mention for extraordinary achievement was addressed to the application Záchranka, which localizes the injured using GPS. The award ceremony took place on November 26, 2019, in Charles University’s Carolinum in Prague. Congratulations to the awardees!

From November 4 to November 8 2019, the Biomedical Center of our Faculty hosted esteemed international visitors. Following up upon a long-term collaboration including one international grant funded from the Erasmus+ program, we had the honor to welcome two professors from Rome. Prof. Alberto Paoluzzi from Italian Roma Tre University and Prof. Antonio DiCarlo from CECAM-IT-SIMUL Node are specialized in the field of computational modeling and object representation. Their invited lectures “Finite Boolean Algebras for Solid Geometry Using Julia's Sparse Arrays” and “On the Gap between Solid Modeling and Physics-based Simulation” attracted the attention they deserved. They were also supplemented by a lecture of prof. Dr. Ing. Eduard Rohan, DSc., from the Faculty of Applied Sciences of the University of West Bohemia (called “Multiscale Approaches in Modeling Liver Perfusion”) and by another one of our colleague Miroslav Jirik, Ph.D. (“Software Modeling for Liver Perfusion Research”). The whole meeting also helped us determine the direction of future research within the AMTMI project – Application of Modern Technologies in Medicine and Industry supported from European Regional Development Fund (No. CZ.02.1.01/0.0/0.0/17_048/0007280). 

Biomedical Centre (Laboratory of Cancer Treatment and Tissue Regeneration) and Department of surgery, Faculty of medicine in Pilsen, Charles university invites to the Computer modeling for research of liver perfusion, which will take place on 5th November 2019   in the Biomedical Center. For more information see the attached programme.

The seminar was supported from European Regional Development Fund - Project „Application of Modern Technologies in Medicine and Industry” (No. CZ.02.1.01/0.0/0.0/17_048/0007280).

We participate in Chaperon - a Horizon 2020 Widening project of the Faculty of Medicine in Pilsen aimed at boosting the research excellence of the Biomedical Center by hiring a renown expert in cancer genomics.

The Chaperon ERA Chairs project, officially titled “CHAPERON – ERA Chair Position for Excellent Research in Oncology“, has been ceremonially initiated by the Chaperon Kick-off Meeting held on September 26, 2019, at the Biomedical Center, Faculty of Medicine in Pilsen, Charles University.

The guests were greeted by Prof. Milan Štengl, MD, PhD – the coordinator of the project and scientific director of the Biomedical Center. The goals of the project as well as its current status were then introduced by Assoc. prof. Václav Liška, MD, PhD. At the moment, the selection procedure of the ERA Chair holder is in progress and its results should be known by the middle of November. The ERA Chair holder is the key person of the project – this position will be occupied by a renowned expert who will build and lead a new laboratory at the Biomedical Center (Laboratory of Translational Cancer Genomics) and boost the excellence of the Center and the Faculty thanks to his/her excellence and managerial skills.

Members of the Faculty management, our research collaborators from the University of West Bohemia together with other honoured guests then proceeded to a brief tour of the Biomedical Center, its laboratories as well as the experimental animal surgery and intensive care facility. The event was then closed by a networking lunch.

The Chaperon project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 856620.

The Summer School of Experimental Surgery 2019 is over! Thanks to all of the record-breaking number of students for coming and working hard during the practical surgery sessions.

News and details from the Summer School are available on the SSES website and SSES facebook page.

Ondřej Brzoň (in the picture second from the right), a student from our team, has won the first prize of the pre-graduate section of the Students' Science Conference of the Faculty of Medicine in Pilsen. Ondřej presented the work "Anaesthesia and intensive care during allogeneous liver transplantation in a big animal" by the authors O. Brzoň, R. Pálek, J. Rosendorf, J. Dejmek, L. Bolek, V. Tégl, L. Bednář, R. Dvořák, J. Slobodová, V. Liška and J. Beneš. Congratulations Ondřej!

From May 25 to May 27 2018 a meeting called «The Contribution of Pharmacogenomics to the Diagnosis and Treatment of Generalized Colorectal Carcinoma IX» took place at a lovely setting of a mountain hut at Javorná.

The meeting was held in a friendly non-formal fashion and a total of 40 researchers from the Laboratory of Cancer Treatment and Tissue Regeneration, Laboratory of Tumor Biology and Laboratory of Pharmacogenomics of the Biomedical Center, and also from the Department of Toxicogenomics (National Institute of Public Health) and Institute of Experimental Medicine (Czech Academy of Sciences) participated at the event. 19 research reports were presented and followed by a lively scientific discussion.

A part of the event was dedicated to the first team meeting of the project UNCE/MED/006: Centrum of Clinical and Experimental Liver Surgery. During the weekend, preliminary results of the featured research were discussed and the course of future work and collaboration was planned. Aside from the scientific program, a hiking trip to the hills of Šumava stimulated the participants on Saturday.

Last week, our book Experimental Surgery was awarded the Maydl Prize of the Czech Medical Association of J. E. Purkyně. The was originally intended as a textbook for our Summer School of Experimenta Surgery, but grew well past this goal during its creation, so we believe that it can be useful for many medical students and Ph.D. students interested in surgery and biomedical research in general.

Liska V. (ed.) et al. Experimental Surgery. Pilsen: Nava, 2016. ISBN 978-80-7211-490-0.