News

PF 2023

(December 21, 2022)

We wish you a joyful holiday season and the best of luck and happiness for 2023!

Applications for the Summer School of Experimental Surgery 2023 (along with the early bird discount) are still open at www.sses.eu.

Applied patches on a defect on the small intestine (left), ultrasound detection of the patches in vivo in active (middle) and non-active state (right)

Article by the Laboratory of Cancet Treatment and Tissue Regeneration published in Nature Communications

The team of the Cancer Treatment and Tissue Regeneration Laboratory together with the research team from ETH Zürich led by prof. Inge Hermann published the article Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment in the journal Nature Communications (IF 14.92, Q1). The project deals with the issue of anastomotic leak in digestive tract surgery and the development of an innovative patch for defects and anastomoses on the digestive tract. The task of the patch is both the prevention of the leak itself as well as its early diagnosis, which is ensured by its diagnostic components. If these components come into contact with the digestive tract, there is a change in the structure of these particles and thus a change in their echogenicity during sonography and a change in their density in a CT scan. This phenomenon enables early diagnosis of postoperative leak, which is essential for the prognosis of patients with this complication.

State award for Prof. Vladislav Třeška

(November 1, 2022)

On the occasion of the national holiday, on October 28, 2022, the President of the Czech Republic, Miloš Zeman, awarded the First Class Merit Medal to Professor Vladislav Třeška, among others, for services to the state in the field of science and education. Representatives of Charles University are among the other new holders of the First Class Medal of Merit, the medal for heroism in memoriam awarded by the President to several students and student representatives of the Charles University executed on November 17, 1939.

Prof. MUDr. Vladislav Třeška, DrSc., is a graduate of the Faculty of Medicine in Pilsen, Charles University. As a native of Pilsen, he has remained loyal to his city to this day, even in the role of a renowned surgeon at the Department of Surgery in Pilsen University Hospital, where he has been the head for many years. Thanks to his professional work and successful medical practice, he became a world-renowned expert, especially in the field of transplantology, vascular and liver surgery. In these fields, he introduced a number of unique original methods that are applied in clinical practice. He was thus responsible for significant advances in medicine in the 21st century. Thanks to these key merits, he also became the head of the Transplantation Center in Pilsen. He participated in repeated internships at surgical clinics in Great Britain, the USA and Hong Kong.

Prof. Třeška works at the Medical Faculty of the Charles University in Pilsen as vice-dean for doctoral studies, habilitation and appointment procedures. For more than 30 years, he has been teaching to both Czech and foreign medical students, including post-graduate students – as a supervisor he led 10 doctoral students, all of whom defended their Ph.D.

His research and publication works (H index 23) are also significant, as well as his membership in many professional societies at the Czech and European level. He is the author or co-author of 19 monographs focusing on the above-mentioned professional topics. He is a frequently invited speaker and visiting professor in Europe, USA and Japan. He is the holder of many prizes and medals, especially for the creation of educational texts and important professional monographs.

One of our PhD student at the Institute of Biomechanics, Graz Technical University (Austria)

(October 17, 2022)

Our PhD student, Ing. Massaro, just came back from an intenship in Graz, Austria, were she spent several weeks performing mechanical testing of some decellularized scaffolds for one of our projects. The internship is insidw the Institute of Biomechanics at Graz Technical University, led by Prof. Holzapfel (https://www.biomech.tugraz.at/). The intership was done as part of the START Project (START/MED/027) to characterize the decellularized caval veins with specific focus on the mechanical behaviour. The samples are mounted on the machine and then inflated at the physiologic pressure while they are immersed in a saline solution at 37°C to simulate the in vivo environment. Tests were done for native caval veins and for decellularized scaffolds to study the effects of cells removal on the tissue biomechanics.

Prof. Holzapfel Lab is focused on the application of Experimental and Computational Mechanics to soft tissues, with specific studies on the blood vessels, stomach tissue or brain both in health and disease conditions.

Our Lab at the IX Congress of Hepato-Pancreato-Biliary Surgery

(October 10, 2022)

Last month, between 19-20th september, members of our Team participated to the IX Congress of Hepato-Pancreato-Biliary Surgery here in Plzen (HPB2022, https://www.chirurgieplzen2022.cz/) were we presented our research during several presentations. It was the meeting of the Czech Surgical Society and evidenced the importance of collaboration between the researchers at the University and the doctors at the hospitals in the development of new technologies for heathcare. Talks were given by Prof. Liška, Prof. Třeška, Dr. Moulisová, Dr. Brůha, Dr. Pálek, Dr. Rosendorf, Ing. Jiřík, Ing. Massaro, and by our main collaborators from the Laboratory of Translational Cancer Genomics (Prof. Hemminki, Dr. Ambrozkiewicz, Dr. Trailin), from the Department of Anaesthesiology and Resuscitation (Prof. Beneš), from the Department of Biophysics (Dr. Bolek) and from the Department of Imaging Methods (Prof. Mírka). Some collaborators and students attended the congress as passive participants (Dr. Lenka Červenková, Dr. Sima Šarčević, Jan Ševčík, Lucie Kepková, Táňa Drhovská).

Visit and seminar by Dr. David Hughes

(September 21, 2022)

Working meeting of principal representatives of research groups, collaborating together in frame of international projects ERA Chair Chaperon and Inter-Cost, took place in Pilsen on September 12-15, 2022. On September 13, 2022, the Faculty of Medicine in Pilsen hosted a very interesting lecture entitled "Exploring two aspects of colorectal cancer development: genetically determined BMI at different lifestages and gut barrier dysfunction" which was delivered by the distinguished guest of the meeting, Dr. David Hughes. Dr. David Hughes is a fellow of the Conway Institute and co-director of the Cancer Biology & Therapeutics Laboratory, University College Dublin (UCD). He is a Governing Council Member of the Irish Cancer Epidemiology Network and the International Society for Selenium Research and a Working Group Member of the European Prospective Investigation into Cancer and Nutririon (EPIC) study. Dr. Hughes collaborates with the Faculty of Medicine in Pilsen thanks to EU funded Inter-COST program TRANSCOLONCAN, Action no.: CA17118.

The lecture was followed by a lively discussion on the given issue and new topics for further cooperation were discussed. As part of team building, a friendly meeting took place in a local restaurant, and the following day some of us took part in a trip to the nearby Bečov nad Teplou, Kladská and Mariánské Lázně.

The meeting was thus very beneficial in terms of current and future scientific cooperation and for strengthening working relationships.

One of our PhD students at the TERMIS EU Chapter 2022 in the beautiful Krakow (Poland)

(July 5, 2022)

Last week the Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter 2022 (https://eu2022.termis.org/) took place at the ICE Congress Center in Krakow (Poland) from 28th June to 1st July and was attended by our PhD student Maria Stefania Massaro. She presented a poster about our decellularization technique for whole porcine liver and in-house developed bioreactors for small scaffold pieces repopulation with cells. The meeting was attended by around 800 researchers representing 40 countries and TERMIS is internationally recognized to be the most famous society about tissue engineering. The poster attracted the curiosity of other researcher and information about liver tissue engineering was shared. The podium presentations, that lasted for three and a half consecutive days with 5 parallel symposia each block, were about biofabrication and 3D printing, polymeric electrospinning, tissue decellularization, organoids and bioreactors to cyte some. A symposium on Tissue Engineering in the Czech Republic was the opportunity to met with other Czech Universities across our country, from Giancarlo Forte’s laboratory at St. Anne’s University Hospital and Josef Jaros (Masaryk University) in Brno, to Pavla Jendelova from the Czech Academy of Sciences in Prague and Miroslava Rysova from the Technical University in Liberec.

The organizing committee provided plenty of opportunity for networking both among young researchers, but also with the sponsoring companies and principal investigators or departments directors during the meeting.


A course on advanced surgery techniques tested our education skills

(June 29, 2022)

Last week, we hosted a surgical course of the Johnson&Johnson Institute called Scenario Planning in Abdominal Surgery (photos on our facebook). The program's highlight was managing complications in laparoscopic abdominal surgery as well as a demonstration of stapling techniques – things that we don't do at the Summer School. Nevertheless, you need to walk before you can run, so that's why we are looking forward to teaching you the basics of surgery at the Summer School, starting next week!

Our team at the XLIII Days of Medical Biophysics congress in Bořetice (Moravia)

(June 15, 2022)

Members of our team attended the XLIII DLB (Dný Lékařské Biofyziky) organized by the Czech-Slovak Society of Biophysics at Hotel Kravi Hora in Bořetice from 25th to 27th May. It was an opportunity to share our work related to tissue engineering and strenghten our collaboration with the Department of Biophysics of our Faculty.

More info, in Czech only, available here https://dlb2022.cz/

New courses for PhD students brought to life with Chaperon

(June 21, 2022)

In collaboration with the Horizon 2020 Chaperon project, we are glad to announce that the first three courses of Chaperon's ERA Research Club for PhD students and young researchers are now permanently available in e-learning form on CUNI's Moodle platform.

The main aim of the ERA Research Club is to provide the necessary support for designing, conducting, analyzing and disseminating research work. Its curriculum is designed to utilize varying opportunities and media to enable the trainees to achieve their professional goals. The content of the courses is accessible after login and enrolment, but below is a short summary of the courses, which are:

  • PROPER course - Protocol, Reviewing, Ownership and Publishing in Experimental Research
    Module 1A focuses on the different types of study design. Study design will determine several things including
    the study methodology, data analysis and requirements for study reporting. Module 1B presents a basic, yet comprehensive way of structuring study protocols to ensure they comply with international recommendations. Module 2 demonstrates a structured, objective and efficient strategy for peer review of studies. At the end of this module, students will be familiar with standardized reporting checklists that will enable them to critically appraise the literature based on study design. It will also give the basic building blocks of what is required when reporting one's own work. Module 3 tells Who is Who, the Can and Can’t do and what should be known before starting a research project. And, finally, module 4 will help the trainees write their research papers using a structured iterative process.

  • Project management
    In its first module, the course focuses on the overall structure of the Horizon Europe program. The second, more practically oriented module provides details on the mobility-targeting Marie Sklodowska-Curie actions from the Horizon Europe portfolio. The final, third module presents the financial rules of Horizon Europe projects and demonstrates how to assemble and present their budget in the project proposal.

  • Basics of Graphics and Image Editing
    This course gives an overview of two basic styles of electronic image representation, i.e. raster and vector graphics. It also explains how color works in computer graphics. Then, different aspects of photos (noisy images acquired from the physical world) and graphics (usually noisless images generated electronically) are explained. It then proceeds to the introduction to the concept of an image being represented by an array of numbers, which is then expanded by explaining what is going on when we adjust the brightness, contrast, levels or colors of the image, as well as providing basic information on the size and resolution of an image and how these can be changed. At the end, practical tips on working with images in MS Office programs and a demonstration of how to assemble a panel figure (A, B, C, D...) for a research paper are given. All topics are accompanied by numerous practical exercises.

Cancer research reigned over Javorná for the eleventh time

(May 25, 2022)

From May 20th to 22nd, another instalment of the regular scientific meeting took place, bringing together collaborating research teams of not only the Faculty of Medicine in Pilsen but also experts from the Institute of Experimental Medicine of the Czech Academy of Sciences and from the National Institute of Public Health. The meeting called The Benefits of Pharmacogenomics for the Diagnostics and Treatment of Generalized Colorectal Carcinoma was held for the eleventh time close to the natural wonders of the Šumava National Park near the village of Čachrov. In total, 43 researchers participated, including also our new foreign colleagues and students this year. The agenda consisted mostly of presentations of recent research results of individual participants. The event was also a coordination meeting of the project UNCE/MED/006: Centrum of clinical and experimental liver surgery and a part of the series of Lab meetings of the Chaperon Horizon 2020 project. The program was divided into two evenings, both packed with research presentations followed by vivid discussion. There was also time for new research topic proposals and discussion of technical, organizational, and scientific issues of the ongoing projects. Also, Saturday morning was dedicated to a hike to the Pancíř mountain, which was endorsed by beautiful sunny weather. The meeting provided an extraordinary inspiration and motivation for further research and, last but not least, it helped to bring the collaborating teams closer again after the covid-induced isolation.

Ph. D. Positions Opening Now

at the Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Czech Republic

(February 16, 2022)

Students for the following Ph.D. study topics are sought in the doctoral study programme:


DNA damage and its repair in mitochondrial DNA, implications in cancer cell*

Tutor: Pavel Vodička

Telomere homeostasis in interaction with DNA damage response in solid carcinogenesis*

Tutor: Pavel Vodička

Genomic/chromosomal instability in relation to microenvironment in colorectal cancer*

Tutor: Ludmila Vodičková

Tumor heterogeneity in colorectal carcinogenesis*

Tutor: Veronika Vymetálková

Modelling of vessel tree in porcine liver based on multi-domain CT scans*

Tutor: Miroslav Jiřík

MicroRNA profiling in hepatocellular carcinoma

Tutor: Filip Ambrozkiewicz

Differences in miRNA profile between colorectal cancer and colorectal cancer liver metastasis

Tutor: Filip Ambrozkiewicz

Immunohistochemical and transcriptional proling of dierent subregions in hepatocellular carcinoma

Tutor: Andriy Trailin

Immune cell landscape in primary and metastatic colorectal cancer

Tutor: Andriy Trailin

Genetic differences between primary and metastatic tumord from same patients

Tutor: Kari Hemminki


Application deadline: April 30, 2022

More about us: www.liskalab.eu, www.biomedic-plzen.cz, www.lfp.cuni.cz

Contact:

Barbora Stachová, barbora.stachova@lfp.cuni.cz

Tel: +420 377 593 467

Department of Science and Research

Charles University, Faculty of Medicine in Pilsen


*This topic could also be studied in Czech language


Novel model of liver microperfusion

(December 21, 2021)


Understanding of liver parenchyma regeneration, which a long-term research topic of the Laboratory of Cancer Treatment and Tissue Regeneration, is crucial for further development of hepatic surgery. In our collaboration with the Department of Mechanics of the Faculty of Applies Sciences, University of West Bohemia, we address this issue using mathematical modelling of liver perfusion with respect to hepatic microanatomy. As one of the results of this effort, a new periodic microanatomical unit – liver representative periodic cell – has been proposed as an alternative to the classical representation originating from the histological structure of the liver. The design of this new unit is based on the geometric characteristics of the liver lobe structure in relation to a multiscale perfusion model derived using the theory of porous media with so-called ‘dual porosity’, which represents the capillary vasculature. The team led by prof. Ing. Eduard Rohan, DrSc., have recently published this result in a Q1 journal PLoS One. The publication was supported by the joint project of the University of West Bohemia and the Faculty of Medicine in Pilsen, Charles University, called AMTMI: Application of Modern Technologies in Medicine and Industry CZ.02.1.01/0.0/0.0/17_048/0007280.

Rohan E., Camprová-Turjanicová J., Liška V.: Geometrical model of lobular structure and its importance for the liver perfusion analysis, PLoS One. 2021 Dec 2;16(12):e0260068. doi: 10.1371/journal.pone.0260068.

prof. MUDr. Václav Liška, Ph.D.


PF 2022

(December 13, 2021)

We wish you a lot of joy & happiness in the upcoming holiday season and beyond!

Also, if you want to actively contribute to your happiness in 2022, join us for the July Summer School in Pilsen. Applications (along with the early bird discount) are still open at www.sses.eu.


Josef Hlávka Foundation Award for employees of our laboratory

(December 1, 2021)

Based on the proposal of the rectors of Czech universities, the Josef, Marie and Zdeněk Hlávka Foundation awards talented university students every year. This is a prestigious award, the award ceremony is associated with the celebration of the holiday of November 17th. For the Faculty of Medicine in Pilsen, MUDr. Jáchym Rosendorf, Ph.D., a recent graduate of doctoral studies in Surgery, was awarded this prize for exceptional study results. In his study work, he focused on the development and application of nanofibrous materials for healing support in the digestive tract surgery. This is a topic that he continues to address also after the graduation. Last year, the award was given to MUDr. Richard Pálek, Ph.D., also from our laboratory, but the award ceremony did not take place until this year due to a coronavirus pandemic. We congratulate both recent graduates and wish them many more successes.


SSES 2022 Applications OPEN!

(November 11, 2021)

Great news! The application for SSES 2022 is now OPEN. Apply HERE in the early bird round until the end of December. We're looking forward to seeing you in Pilsen next summer.

Ph. D. Positions Opening Now

at the Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Czech Republic

(November 01, 2021)

Students for the following Ph.D. study topics are sought in the doctoral study programme:


DNA damage and its repair in mitochondrial DNA, implications in cancer cell*

Tutor: Pavel Vodička

Telomere homeostasis in interaction with DNA damage response in solid carcinogenesis*

Tutor: Pavel Vodička

Genomic/chromosomal instability in relation to microenvironment in colorectal cancer*

Tutor: Ludmila Vodičková

Tumor heterogeneity in colorectal carcinogenesis*

Tutor: Veronika Vymetálková

MicroRNA profiling in hepatocellular carcinoma

Tutor: Filip Ambrozkiewicz

Immunohistochemical and transcriptional proling of dierent subregions in hepatocellular carcinoma

Tutor: Andriy Trailin

Modelling of vessel tree in porcine liver based on multi-domain CT scans*

Tutor: Miroslav Jiřík

Study of prognostic biomarkers and therapeutic targets in patients with gastrointestinal cancers

Tutor: Viktor Hlaváč


Application deadline: November 30, 2021

More about us: www.liskalab.eu, www.biomedic-plzen.cz, www.lfp.cuni.cz

Contact:

Barbora Stachová, barbora.stachova@lfp.cuni.cz

Tel: +420 377 593 467

Department of Science and Research

Charles University, Faculty of Medicine in Pilsen

*This topic could also be studied in Czech language


SSES 2021 Programme Published

(June 21, 2021)

The programme of the Summer School of Experimental Surgery 2021 has been published on the SSES webpage. It is still subject to minor changes according to current situation, but the main outline should stay the same. Looking forward to seeing you in July!

The Czech Transplantation Society Paper of the Year Prize for 2020 announced

(May 31, 2021)

The Czech Transplantation Society announced the winner of the Best scientific publication of the year 2020. The prize was awarded to RNDr. Vladimira Moulisova, PhD who is the first author of the original research paper “Novel morphological multi-scale evaluation system for quality assessment of decellularized liver scaffolds”. This work was published as an open access paper in Journal of Tissue Engineering (IF 5.352) in May 2020 (https://doi.org/10.1177/2041731420921121). Dr. Moulisova and co-authors (Jiřík M., Schindler C., Červenková L., Pálek R., Rosendorf J., Arlt J., Bolek L., Šůsová S., Nietzsche S., Liška V., Dahmen U) deal here with the highly potential native biomaterial suitable for liver tissue engineering that could facilitate production of transplantable liver tissue grafts in the future. The whole team is very pleased by receiving this prize which was officially awarded to dr. Moulisova by prof. MUDr. Vladislav Třeška, DrSc., the head of the Society , and prof. MUDr. Tomáš Reischig, Ph. D., the research manager of the Society last Friday.

Ph.D. Positions Opening Now

at the Biomedical Center, Faculty of Medicine in Pilsen,

Charles University, Czech Republic

(March 3, 2021)

Students for the following Ph.D. study topics are sought in the doctoral study programme:


Immune cell and mutational landscape of colorectal cancers

Tutor: Kari Hemminki

MicroRNA profiling in hepatocellular carcinoma

Tutor: Filip Ambrozkiewicz

Modelling of vessel tree in porcine liver based on multi-domain CT scans*

Tutor: Miroslav Jiřík

The role of oxysterols in prognosis, progression and therapy of solid tumours*

Tutor: Pavel Souček

Identification and functional characterization of tumor prognostic and predictive

genetic biomarkers in experimental models and patients with solid tumors*

Tutor: Radka Václavíková

Study of prognostic biomarkers and therapeutic targets in patients

with gastrointestinal cancers*

Tutor: Viktor Hlaváč

Tumor heterogeneity in colorectal carcinogenesis*

Tutor: Veronika Vymetálková

DNA damage and its repair in mitochondrial DNA, implications in cancer cell*

Tutor: Pavel Vodička

Telomere homeostasis in interaction with DNA damage response in solid carcinogenesis*

Tutor: Pavel Vodička

Genomic/chromosomal instability in relation to microenvironment in colorectal cancer*

Tutor: Ludmila Vodičková

Application deadline: April 30, 2021

More about us: www.liskalab.eu, www.biomedic-plzen.cz, www.lfp.cuni.cz

Contact:

Barbora Stachová, barbora.stachova@lfp.cuni.cz

Tel: +420 377 593 467

Department of Science and Research, Charles University, Faculty of Medicine in Pilsen


*This topic could also be studied in Czech language



Older news can be found >>> HERE in archive (2016–2020) <<<.